Tetrahedron Letters

Synthesis of N-protected N-methyl serine and threonine

Y Luo, G Evindar, D Fishlock, GA Lajoie

文献索引：Luo, Yue; Evindar, Ghotas; Fishlock, Dan; Lajoie, Gilles A Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3807 - 3809

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被引用次数: 20

摘要

Two efficient and convenient syntheses of N-Cbz and N-Fmoc N-methyl serine and threonine are described. The amino acid side-chain alcohol can be protected as a TBDMS ether in very good yield or left free, followed by the formation and subsequent reduction of the corresponding oxazolidinone.