Novel gonadotropin-releasing hormone antagonists: peptides incorporating modified N. omega.-cyanoguanidino moieties

P Theobald, J Porter, C Rivier, A Corrigan…

文献索引：Theobald, Paula; Porter, John; Rivier, Catherine; Corrigan, Anne; Hook, William; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2395 - 2402

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被引用次数: 34

摘要

Mammalian gonadotropin-releasing hormone (GnRH, pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg- Pro-Gly-NHz), first isolated and characterized by Matsuo et al.'and by Burgus et a1., 2 is well- known to exert regulatory control over reproductive functions. Since ita discovery, thousands of GnRH analogues have been synthesized in a wide-ranging search for potent and long- acting agonists and antagonists for use as therapeutic agents for endocrine diseases and ...