Abstract A new and convenient procedure for the synthesis of 1, 6-naphthyridin-2 (1H)-ones and their derivatives is described. In the first scheme 5-acetyl-6-[2-(dimethylamino) ethenyl]- 1, 2-dihydro-2-oxo-3-pyridinecarbonitrile (4) obtained by the reaction of N, N- dimethylformamide dimethyl acetal with 5-acetyl-1, 2-dihydro-6-methyl-2-oxo-3- pyridinecarbonitrile (3) was cyclized to 1, 2-dihydro-5-methyl-2-oxo-1, 6-naphthyridine-3- ...