Scalable synthesis of a prostaglandin EP4 receptor antagonist

D Gauvreau, SJ Dolman, G Hughes…

文献索引：Wiedemann, Stefan; Frank, Daniel; Winsel, Harald; De Meijere, Armin Organic Letters, 2003 , vol. 5, # 5 p. 753 - 755

全文：HTML全文

被引用次数: 17

摘要

... Volume: Page: ... The Journal of Organic Chemistry. ... Using the modified conditions reported by de Meijere (MeTi(OiPr) 3 , Et 2 Zn, LiI or LiOiPr) failed to afford amine 8.(9) Treating nitrile 10 with Ti(OiPr) 4 , EtMgBr, and BF 3 ·OEt 2 at low temperature (−78 to −40 °C ...