Tetrahedron

Synthesis of the indole alkaloids meridianins from the tunicate Aplidium meridianum

PM Fresneda, P Molina, JA Bleda

文献索引：Fresneda, Pilar M; Molina, Pedro; Bleda, Juan A Tetrahedron, 2001 , vol. 57, # 12 p. 2355 - 2363

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被引用次数: 90

摘要

The marine natural products meridianins A and C–E have been synthesized for the first time starting from the appropriate N-tosyl-3-acetylindole. A facile two-step conversion of N-tosyl-3- acetylindoles to the corresponding meridianins by treatment with dimethylformamide dimethylacetal and further cyclization of the resulting enaminone with aminoguanidine is described. This method has also been applied for the preparation of the 3-[(2-amino) ...