Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

O Chahrour, A Abdalla, F Lam, C Midgley…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3066 - 3069

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被引用次数: 8

摘要

... Bioorganic & Medicinal Chemistry Letters. ... The synthetic chemistry employed to prepare Class I–III compounds is outlined in Scheme 1. The synthesis started from 2-(4-methoxy-3-nitrobenzylthio) acetic acid 1, which can be obtained by halogenation of 1-methoxy-4-methyl-2 ...