Tetrahedron: Asymmetry

Unusual amino acids IV. Asymmetric synthesis of thienylalanines

C Döbler, HJ Kreuzfeld, HW Krause, M Michalik

文献索引：Doebler, Christian; Kreuzfeld, H.-J.; Krause, H. W.; Michalik, M. Tetrahedron: Asymmetry, 1993 , vol. 4, # 8 p. 1833 - 1842

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被引用次数: 19

摘要

Abstract (Z)-2-N-Acylamino-3-thienyl-acrylic acids and their esters were prepared by known procedures and hydrogenated to the corresponding optically active 2-N-acetyl (or benzoyl)- 3-(2-or 3-thienyl)-alanines with optical yields up to 90% using the rhodium complexes of “PROPRAPHOS” 6a, b and O, N-bis (diphenylphosphino)-2-exo-hydroxy, 3-endo- methylamino-norborane 6c as chiral catalysts. Recrystallization and deacylation of the ...