The reaction of aliphatic aldehydes and ketones with 2-hydrazinoadenosine under relatively mild conditions (at room temperature or in refluxing methanol) formed 2-(N/- alkylidenehydrazino)-adenosines, 5-22, in good yields. Two kinds of adenosine receptors regulate cardiac and coronary physiology. In supraventricular tissues an AlAR coupled to muscarinic K channels mediates the negative chronotropic, dromotropic, and inotropic ...
[Van Tilburg, Erica W.; Von Frijtag Drabbe Kuenzel, Jacobien; De Groote, Miriam; IJzerman, Ad P. Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 420 - 429]
