A series of furo [3, 2-b] indole carboxylic acids, tetrazoles, and carbamoyltetrazoles was prepared and tested in vitro with use of a model of active pulmonary anaphylaxis, the modified Schultz-Dale Test (SDT). In this model, isolated guinea pig lung strips are repeatedly challenged with antigen in the presence of an antihistamine (HJ. Most of the acidic furo [3, 2-b] indoles tested inhibited the leukotriene-mediated lung contraction in a ...
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