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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

2, 4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 10. 2, 4-Diamino-5-(6-quinolylmethyl)-and-[(tetrahydro-6-quinolyl) methyl] pyrimidine …

BS Rauckman, MY Tidwell, JV Johnson…

文献索引：Rauckman; Tidwell; Johnson; Roth Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1927 - 1935

全文：HTML全文

被引用次数: 40

摘要

A series of 18 2, 4-diamino-5-[(1, 2, 3, 4-tetrahydro-6-quinolyl) methyl] pyrimidines has been prepared by the condensation of 2, 4-diamino-5-(hydroxymethyl) pyrimidine with 1, 2, 3, 4- tetrahydroquinolines in acidic medium. Several derivatives were catalytically aromatized; others were synthesized from these by routine aromatic substitution or by condensations of (anilinomethy1) pyrimidines to give quinolinylmethyl analogues. Compounds with 4- ...

2,4-diamino-5-(1,2,3,4-tetrahydro-4-methyl-6-quinolylmethyl)-pyrimidine dihydrochloride结构式

2,4-diamino-5-(...

~53%

5-[[8-(2-methoxyethoxy)quinolin-6-yl]methyl]pyrimidine-2,4-diamine结构式

5-[[8-(2-methox...

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4-甲基喹啉结构式

~%

5-[[8-(2-methoxyethoxy)quinolin-6-yl]methyl]pyrimidine-2,4-diamine结构式

5-[[8-(2-methox...

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2,4-二氨基-5-羟甲基嘧啶结构式

2,4-二氨基-5-羟甲基嘧啶

~%

5-[[8-(2-methoxyethoxy)quinolin-6-yl]methyl]pyrimidine-2,4-diamine结构式

5-[[8-(2-methox...

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1,2,3,4-四氢-4-甲基喹啉结构式

1,2,3,4-四氢-4-甲基喹啉

~%

5-[[8-(2-methoxyethoxy)quinolin-6-yl]methyl]pyrimidine-2,4-diamine结构式

5-[[8-(2-methox...

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4-甲基喹啉结构式

冰醋酸结构式

~30%

1,2,3,4-四氢-4-甲基喹啉结构式

1,2,3,4-四氢-4-甲基喹啉

1-ethyl-4-methyl-3,4-dihydro-2H-quinoline结构式

1-ethyl-4-methy...

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4-Chloro-5,8-dimethoxy-quinoline-3-carboxylic acid ethyl ester结构式

4-Chloro-5,8-di...

~13%

ethyl 5,8-dimethoxyquinoline-3-carboxylate结构式

ethyl 5,8-dimet...

ethyl 1,2,3,4-tetrahydro-5,8-dimethoxy-3-quinolinecarboxylate结构式

ethyl 1,2,3,4-t...

3-Quinolinecarboxylicacid, 4-chloro-5,8-dimethoxy-, ethyl ester结构式

3-Quinolinecarb...

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ethyl 1,4-dihydro-5,8-dimethoxy-4-oxo-3-quinolinecarboxylate结构式

ethyl 1,4-dihyd...

~%

3-Quinolinecarboxylicacid, 4-chloro-5,8-dimethoxy-, ethyl ester结构式

3-Quinolinecarb...

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3-戊烯-2-酮结构式

5-[(4-amino-3-methoxyphenyl)methyl]pyrimidine-2,4-diamine结构式

5-[(4-amino-3-m...

~6%

5-[(8-methoxy-4-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxy-4...

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2,4-二氨基-5-羟甲基嘧啶结构式

2,4-二氨基-5-羟甲基嘧啶

~%

5-[(8-methoxy-4-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxy-4...

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邻氨基苯甲醚结构式

邻氨基苯甲醚

~%

5-[(8-methoxy-4-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxy-4...

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5-((8-methoxy-4-methyl-1,2,3,4-tetrahydroquinolin-6-yl)methyl)pyrimidine-2,4-diamine hydrochloride结构式

5-((8-methoxy-4...

~16%

5-[(4-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4-methylqui...

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8-Methoxylepidine结构式

8-Methoxylepidine

~%

5-[(4-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4-methylqui...

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2-羟基-4-甲基-8-甲氧基喹啉结构式

2-羟基-4-甲基-8-甲氧基喹啉

~%

5-[(4-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4-methylqui...

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8-methoxy-4-methyl-1,2,3,4-tetrahydro-quinoline结构式

8-methoxy-4-met...

~%

5-[(4-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4-methylqui...

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2-羟基-4-甲基-8-甲氧基喹啉结构式

2-羟基-4-甲基-8-甲氧基喹啉

~97%

8-Methoxylepidine结构式

8-Methoxylepidine

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4-Chloro-5,8-dimethoxy-quinoline-3-carboxylic acid ethyl ester结构式

4-Chloro-5,8-di...

~10%

ethyl 5,8-dimethoxyquinoline-3-carboxylate结构式

ethyl 5,8-dimet...

ethyl 1,2,3,4-tetrahydro-5,8-dimethoxy-3-quinolinecarboxylate结构式

ethyl 1,2,3,4-t...

3-Quinolinecarboxylicacid, 4-chloro-5,8-dimethoxy-, ethyl ester结构式

3-Quinolinecarb...

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ethyl 1,4-dihydro-5,8-dimethoxy-4-oxo-3-quinolinecarboxylate结构式

ethyl 1,4-dihyd...

~%

ethyl 5,8-dimethoxyquinoline-3-carboxylate结构式

ethyl 5,8-dimet...

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5-[[8-(2-methoxyethoxy)quinolin-6-yl]methyl]pyrimidine-2,4-diamine结构式

5-[[8-(2-methox...

~52%

5-[(8-methoxy-2,4-dimethylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxy-2...

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4-甲基喹啉结构式

~%

5-[(8-methoxy-2,4-dimethylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxy-2...

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2,4-二氨基-5-羟甲基嘧啶结构式

2,4-二氨基-5-羟甲基嘧啶

~%

5-[(8-methoxy-2,4-dimethylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxy-2...

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1,2,3,4-四氢-4-甲基喹啉结构式

1,2,3,4-四氢-4-甲基喹啉

~%

5-[(8-methoxy-2,4-dimethylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxy-2...

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2,4-diamino-5-(1,2,3,4-tetrahydro-4-methyl-6-quinolylmethyl)-pyrimidine dihydrochloride结构式

2,4-diamino-5-(...

~%

5-[(8-methoxy-2,4-dimethylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxy-2...

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8-chloro-2,4-dimethylquinoline结构式

8-chloro-2,4-di...

~%

8-chloro-2,4-dimethyl-1,2,3,4-tetrahydroquinoline结构式

8-chloro-2,4-di...

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3-戊烯-2-酮结构式

~%

8-chloro-2,4-dimethyl-1,2,3,4-tetrahydroquinoline结构式

8-chloro-2,4-di...

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2-氯苯胺结构式

~%

8-chloro-2,4-dimethyl-1,2,3,4-tetrahydroquinoline结构式

8-chloro-2,4-di...

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2,4-Diamino-5-(1,2,3,4-tetrahydro-8-methoxy-6-quinolylmethyl)pyrimidine结构式

2,4-Diamino-5-(...

~20%

5-[(8-methoxyquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxyqu...

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1,2,3,4-tetrahydro-8-(methoxyethoxy)quinoline结构式

1,2,3,4-tetrahy...

~%

5-[(8-methoxyquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxyqu...

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8-羟基喹啉结构式

~%

5-[(8-methoxyquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(8-methoxyqu...

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