5-Fluorouracil derivatives. I. The synthesis of 1-carbamoyl-5-fluorouracils.

S Ozaki, Y Ike, H Mizuno, K Ishikawa…

文献索引：Ozaki; Ike; Mizuno; et al. Bulletin of the Chemical Society of Japan, 1977 , vol. 50, # 9 p. 2406 - 2412

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被引用次数: 132

摘要

The toxicity and tumor affinity of 5-fluorouracil (1) have been modified by the introduction of a carbamoyl group. Carbamoylation by three general methods were studied extensively:(i) The reaction of 1 with isocyanate,(ii) the reaction of 1-chloroformyl-5-fluorouracil with amine, and (iii) the reaction of 1 with carbamoyl chloride. These three methods usually give 1- carbamoyl-5-fluorouracils (2). 3-Carbamoyl-5-fluorouracils were not obtained by any ...