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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

. alpha.-Amino carbanions via formamidines. Alkylation of pyrrolidines, piperidines, and related heterocycles

AI Meyers, PD Edwards, WF Rieker…

文献索引：Meyers,A.I.; Edwards,P.D.; Rieker,W.F. Journal of the American Chemical Society, 1984 , vol. 106, p. 3270

全文：HTML全文

被引用次数: 106

摘要

Abstract: a-Metalation of piperidine, pyrrolidine, hexahydroazepine, 1, 3-thiazolidine, and 1, 3-thiazane has been accomplished via their N-tert-butylformamidine derivatives. Alkylation of these a-amino carbanions via their lithio or cuprate derivatives leads to good yields of a- substituted heterocycles. Similarly, 1, 2, 5, 6-tetrahydropyridine metalates at the 2 position, but alkylates at the 4 position. Reduction leads to 4-substituted piperidines. Evidence is ...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(2-methylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

2-Propanamine, 2-methyl-N2-[1-tetrahydro-1H-1-pyrrolylmethylidene]结构式

2-Propanamine, ...

碘甲烷结构式

~%

N-tert-butyl-1-(2-methylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(2-butylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

正溴丁烷结构式

2-Propanamine, 2-methyl-N2-[1-tetrahydro-1H-1-pyrrolylmethylidene]结构式

2-Propanamine, ...

~%

N-tert-butyl-1-(2-butylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(2-heptylazepan-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-(2-heptylazepan-1-yl)methanimine结构式

N-tert-butyl-1-...

~82%

2-heptylazepane结构式

2-heptylazepane

tert-Butyl-[1-(4-cyclohexyl-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine结构式

tert-Butyl-[1-(...

~51%

4-Cyclohexylpiperidine结构式

4-Cyclohexylpip...

1-(2-benzylpyrrolidin-1-yl)-N-tert-butylmethanimine结构式

1-(2-benzylpyrr...

~92%

2-苄基吡咯烷结构式

2-苄基吡咯烷

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(2-prop-2-enylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

2-Propanamine, 2-methyl-N2-[1-tetrahydro-1H-1-pyrrolylmethylidene]结构式

2-Propanamine, ...

烯丙基溴结构式

~%

N-tert-butyl-1-(2-prop-2-enylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(2-phenylselanylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(4-butyl-3,4-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

正溴丁烷结构式

N-tert-butyl-1-(3,6-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

~%

N-tert-butyl-1-(4-butyl-3,4-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-(2-prop-2-enylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

~78%

2-(2-propen-1-yl)-Pyrrolidine结构式

2-(2-propen-1-y...

Piperidine,4-(diphenylmethyl)-结构式

Piperidine,4-(d...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~60%

1-(4-benzhydrylpiperidin-1-yl)-N-tert-butylmethanimine结构式

1-(4-benzhydryl...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(2-methylpiperidin-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-piperidin-1-ylmethanimine结构式

N-tert-butyl-1-...

碘甲烷结构式

~%

N-tert-butyl-1-(2-methylpiperidin-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-(2-propylpiperidin-1-yl)methanimine结构式

N-tert-butyl-1-...

~81%

2-丙基哌啶结构式

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(2-butylpiperidin-1-yl)methanimine结构式

N-tert-butyl-1-...

碘代正丁烷结构式

碘代正丁烷

N-tert-butyl-1-piperidin-1-ylmethanimine结构式

N-tert-butyl-1-...

~%

N-tert-butyl-1-(2-butylpiperidin-1-yl)methanimine结构式

N-tert-butyl-1-...

1,2,5,6-四氢吡啶结构式

1,2,5,6-四氢吡啶

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~76%

N-tert-butyl-1-(3,6-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(6-butyl-3,6-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

正溴丁烷结构式

N-tert-butyl-1-(3,6-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

~%

N-tert-butyl-1-(6-butyl-3,6-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(3,4-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-piperidin-1-ylmethanimine结构式

N-tert-butyl-1-...

~%

N-tert-butyl-1-(3,4-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-[2-(cyclopentylmethyl)piperidin-1-yl]methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-piperidin-1-ylmethanimine结构式

N-tert-butyl-1-...

6-溴-1-己烯结构式

~%

N-tert-butyl-1-(3,4-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-[2-(cyclopentylmethyl)piperidin-1-yl]methanimine结构式

N-tert-butyl-1-...

1-(2-benzylpiperidin-1-yl)-N-tert-butylmethanimine结构式

1-(2-benzylpipe...

~85%

2-苄基哌啶结构式

N-tert-butyl-1-(2-butylpyrrolidin-1-yl)methanimine结构式

N-tert-butyl-1-...

~71%

2-丁基吡咯烷结构式

2-丁基吡咯烷

四氢噻唑结构式

N-叔丁基甲酰胺结构式

N-叔丁基甲酰胺

~%

N-tert-butyl-1-(1,3-thiazolidin-3-yl)methanimine结构式

N-tert-butyl-1-...

1,3-thiazinane结构式

N-叔丁基甲酰胺结构式

N-叔丁基甲酰胺

~40%

N-tert-butyl-1-(1,3-thiazinan-3-yl)methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-[2-(3-chloropropyl)piperidin-1-yl]methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-piperidin-1-ylmethanimine结构式

N-tert-butyl-1-...

1-溴-3-氯丙烷结构式

1-溴-3-氯丙烷

~%

N-tert-butyl-1-[2-(3-chloropropyl)piperidin-1-yl]methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-(2-propylazepan-1-yl)methanimine结构式

N-tert-butyl-1-...

N,N-dimethyl tert-butylamino-formamidine结构式

N,N-dimethyl te...

~%

N-tert-butyl-1-[2-(cyclopentylmethyl)piperidin-1-yl]methanimine结构式

N-tert-butyl-1-...

碘甲基环戊烷,含铜稳定剂结构式

碘甲基环戊烷,含铜稳定剂

N-tert-butyl-1-piperidin-1-ylmethanimine结构式

N-tert-butyl-1-...

~%

N-tert-butyl-1-[2-(cyclopentylmethyl)piperidin-1-yl]methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-piperidin-1-ylmethanimine结构式

N-tert-butyl-1-...

~%

N-tert-butyl-1-(3,4-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-[2-(cyclopentylmethyl)piperidin-1-yl]methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-piperidin-1-ylmethanimine结构式

N-tert-butyl-1-...

6-溴-1-己烯结构式

~%

N-tert-butyl-1-(3,4-dihydro-2H-pyridin-1-yl)methanimine结构式

N-tert-butyl-1-...

N-tert-butyl-1-[2-(cyclopentylmethyl)piperidin-1-yl]methanimine结构式

N-tert-butyl-1-...