Tetrahedron Letters

Phosphotriester approach to oligothymidylate synthesis utilizing a simple thymidine unit and a new type of condensing agents

M Sekine, J Matsuzaki, T Hata

文献索引：Sekine, Mitsuo; Matsuzaki, Jun-ichi; Hata, Tsujiaki Tetrahedron Letters, 1981 , vol. 22, # 33 p. 3209 - 3212

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被引用次数: 56

摘要

Abstract DMTrTp (SPh) 2 was proposed as a simplest “nucleotide unit” for the synthesis of olygothymidylates. One phenylthio group was removed selectively and rapidly from dithiol- esters by 1 M pyridinium hypophosphonate. Two kinds of arenedisulfonyl chlorides were newly prepared and utilized as promising condensing agents.