Cerium (IV)??Catalyzed Deprotection of Acetals and Ketals under Mildly Basic Conditions

…, JM Plancher, Y Quesnel, JC Vanherck

文献索引：Marko, Istvan E.; Ates, Ali; Gautier, Arnaud; Leroy, Bernard; Plancher, Jean-Marc; Quesnel, Yannick; Vanherck, Jean-Christophe Angewandte Chemie - International Edition, 1999 , vol. 38, # 21 p. 3207 - 3209

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被引用次数: 114

摘要

Abstract Smooth and quantitative deprotection of a wide range of acetals and ketals [Eq.(a); R, R 1= alkyl, aryl, H] under neutral to mildly basic conditions was achieved with catalytic quantities of cerium ammonium nitrate (CAN). The reaction conditions are compatible with a variety of sensitive functional groups, and aldehydes can be liberated from acetals without being oxidized to the corresponding carboxylic acids.