Diclofenac derivatives with insulin-sensitizing activity

JT Wang, Y Wang, JQ Zhang, X Cui, Y Zhang…

文献索引：Wang, Jian Ta; Wang, Ying; Zhang, Ji Quan; Cui, Xing; Zhang, Yi; Zhu, Gao Feng; Tang, Lei Chinese Chemical Letters, 2011 , vol. 22, # 4 p. 409 - 412

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被引用次数: 2

摘要

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia as well as insulin resistance. Recently T2DM was also presumed as a chronic inflammation disease [1]. Studies showed that inflammatory cytokines such as C-reactive protein (C-RP), interleukins (ILs), tumor necrosis factor-alpha (TNF-α), plasminogen activator inhibitor type 1 (PAI-1) probably play a major role in the development of insulin resistance, which is known as important ...