Design and synthesis of novel polycycles based on the 3H??pyrrolo/6, 7??dihydropyrido [1, 2??a] indole scaffold as templates for pharmaceutical development

…, N Pala, V Sanna, R Dallocchio, A Dessì…

文献索引：Derudas, Marco; Pala, Nicolino; Sanna, Vanna; Dallocchio, Roberto; Dessi, Alessandro; Roggio, Anna Maria; Sechi, Mario Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1161 - 1168

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被引用次数: 1

摘要

Abstract In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, we designed and synthesized several polycyclic templates as potential substrates to be used in drug design. We obtained a set of condensed ring systems as versatile structural platforms to generate potential DNA-interactive agents and/or reversible inhibitors of enzymes such as topoisomerases, poly (ADP-ribose) polymerase-1 (PARP-1), ...