Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors

DV Kumar, C Hoarau, M Bursavich, P Slattum…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 13 p. 4377 - 4385

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被引用次数: 16

摘要

... Bioorganic & Medicinal Chemistry Letters. Volume 22, Issue 13, 1 July 2012, Pages 4377–4385. ... Medicinal Chemistry, Myrexis Inc., 305 Chipeta Way, Salt Lake City, UT 84108, USA; ... Physico-chemical and ADME properties were optimized to improve oral bioavailability in mouse. ...