Large-scale preparation of 2-methyloxazole-4-carboxaldehyde

…, R Chima, N Hussain, ME Popkin, G Roux…

文献索引：Benoit, Georges-Emmanuel; Carey, John S.; Chapman, Alan M.; Chima, Ranjit; Hussain, Nigel; Popkin, Matthew E.; Roux, Guillaume; Tavassoli, Bahareh; Vaxelaire, Carine; Webb, Michael R.; Whatrup, David Organic Process Research and Development, 2008 , vol. 12, # 1 p. 88 - 95

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被引用次数: 13

摘要

The large-scale preparation of 2-methyloxazole-4-carboxaldehyde presents a significant challenge due to the physical characteristics of the molecule. A method for the preparation of 10-kg batches of 2-methyloxazole-4-carboxaldehyde is described. The key reaction is the reduction of the corresponding N-methoxy-N-methyl amide using lithium aluminium hydride, followed by workup and isolation by crystallization.