Polyenylidene Thiazolidine Derivatives with Retinoidal Activities.

…, H FUKASAWA, E KAWACHI, Y HASHIMOTO…

文献索引：Tashima, Toshihiko; Kagechika, Hiroyuki; Tsuji, Motonori; Fukasawa, Hiroshi; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 11 p. 1805 - 1813

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被引用次数: 25

摘要

Several polyenylidene thiazolidinedione or 2-thioxo-4-thiazolidinone derivatives were synthesized and their retinoidal activities were examined in terms of the differentiation- inducing ability towards human promyelocytic leukemia HL-60 cells and inhibitory effect on interleukin (IL)-1α-induced IL-6 production in MC3T3-E1 cells. Compounds containing a trimethylcyclohexenyl ring induced HL-60 cell differentiation with weaker activity than ...