Our previously published synthesis of the N'-pyridyl analog proved preparations of other intermediates are also described. 1 b of thiamine pyrophosphate6) is improved resulting in a re-The N'-pyridylthiamine pyrophosphate analog 1 b has been markably higher yield. Key reaction of this new synthetic separated and purified by ion exchange chromatography on pathway is the oxidative degradation of 5-acetylpyridine 8 to Sephadex A-25. the 5- ...
