Synthetic communications

Synthesis of l??(Alkoxymethyl)??5??benzyl??6??methyluracil as Potential Nonnucleoside HIV??1 RT Inhibitors

Y Chen, Y Guo, H Yang, X Wang, J Liu

文献索引：Chen, Yanli; Guo, Ying; Yang, Hua; Wang, Xiaowei; Liu, Junyi Synthetic Communications, 2006 , vol. 36, # 19 p. 2913 - 2920

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被引用次数: 3

摘要

Abstract 1, 3??Dibenzyl??6??methyl??5??zincbromomethyluracil 6 was prepared starting from 6?? methyluracil 1. The cross??coupling reaction of benzylic zinc reagent 6 with PhI using bis ( dibenzylideneacetone) palladium (0) and (o??furyl) 3P as catalyst gave 1, 3, 5??tribenzyl??6?? methyluracil 7. The N??1, N??3??dibenzyl group could be removed in dealkylation to give the 5?? benzyl??6??methyluracil 8. It was N??1??alkylated with chloromethyl ethyl ether or ...