Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine" acyclic" nucleoside analogs

…, PW Hatfield, J Balzarini, E De Clercq

文献索引：Robins, Morris J.; Hatfield, Peter W.; Balzarini, Jan; Clercq, Eric De Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1486 - 1492

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被引用次数: 56

摘要

Ia R= H b R= CH, OH herpes selectivity from phosphorylation by the virus-encoded deoxythymidine (dThd) kinase.'The resulting acyclovir monophosphate is phosphorylated further by host cell enzyme (s), eg, GMP kinasea8 Acyclovir triphosphate inhibits viral DNA synthesis by preferential binding to the virus-encoded polymeraseg and by incorporation at the growing 3'-end and tight complexing of this terminated DNA fragment with the viral ...