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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

Synthetic studies on the CDEF ring system of lactonamycin

R Le Vézouët, AJP White, JN Burrows, AGM Barrett

文献索引：Le Vezouet, Ronan; White, Andrew J.P.; Burrows, Jeremy N.; Barrett, Anthony G.M. Tetrahedron, 2006 , vol. 62, # 52 p. 12252 - 12263

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被引用次数: 15

摘要

Both (1) furan–maleimide Diels–Alder cycloaddition reaction and (2) furan–benzyne cycloaddition, Suzuki cross-coupling, boron-mediated aldol, and electrophilic aromatic substitution reactions were examined for the construction of the CDEF ring system of lactonamycin (1).

1-methyl-4-(1,5,8-trimethoxy-2-naphthyl)-1,5-dihydro-2-pyrrolone结构式

1-methyl-4-(1,5...

~94%

1-methyl-4-(1,5,8-trimethoxynaphthalen-2-yl)pyrrolidin-2-one结构式

1-methyl-4-(1,5...

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2-bromo-1,5,8-trimethoxynaphthalene结构式

2-bromo-1,5,8-t...

~%

1-methyl-4-(1,5,8-trimethoxynaphthalen-2-yl)pyrrolidin-2-one结构式

1-methyl-4-(1,5...

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未登录结构式

~%

1-methyl-4-(1,5,8-trimethoxynaphthalen-2-yl)pyrrolidin-2-one结构式

1-methyl-4-(1,5...

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3-(1,5,8-trimethoxynaphthalen-2-yl)-2H-furan-5-one结构式

3-(1,5,8-trimet...

~%

1-methyl-4-(1,5,8-trimethoxynaphthalen-2-yl)pyrrolidin-2-one结构式

1-methyl-4-(1,5...

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3,6-二羟基邻苯二甲腈结构式

3,6-二羟基邻苯二甲腈

~%

4,7-dihydroxy-2-methyl-3H-isoindol-1-one结构式

4,7-dihydroxy-2...

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4,7-dihydroxy-2-methyl-2,3-dihydro-1-isoindoledione结构式

4,7-dihydroxy-2...

~30%

4,7-dihydroxy-2-methyl-3H-isoindol-1-one结构式

4,7-dihydroxy-2...

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4,7-dihydroxy-2-methyl-2,3-dihydro-1-isoindoledione结构式

4,7-dihydroxy-2...

溴化苄结构式

~92%

2-methyl-4,7-bis(phenylmethoxy)isoindole-1,3-dione结构式

2-methyl-4,7-bi...

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3,6-二羟基邻苯二甲腈结构式

3,6-二羟基邻苯二甲腈

~%

2-methyl-4,7-bis(phenylmethoxy)isoindole-1,3-dione结构式

2-methyl-4,7-bi...

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4,7-di(benzyloxy)-3-hydroxy-2-methyl-2,3-dihydro-1-isoindolone结构式

4,7-di(benzylox...

~83%

2-methyl-4,7-bis(phenylmethoxy)-3H-isoindol-1-one结构式

2-methyl-4,7-bi...

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4,7-dihydroxy-2-methyl-2,3-dihydro-1-isoindoledione结构式

4,7-dihydroxy-2...

~%

2-methyl-4,7-bis(phenylmethoxy)-3H-isoindol-1-one结构式

2-methyl-4,7-bi...

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2-methyl-4,7-bis(phenylmethoxy)isoindole-1,3-dione结构式

2-methyl-4,7-bi...

~%

2-methyl-4,7-bis(phenylmethoxy)-3H-isoindol-1-one结构式

2-methyl-4,7-bi...

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3,6-二羟基邻苯二甲腈结构式

3,6-二羟基邻苯二甲腈

~%

2-methyl-4,7-bis(phenylmethoxy)-3H-isoindol-1-one结构式

2-methyl-4,7-bi...

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2-methyl-4,7-bis(phenylmethoxy)-3H-isoindol-1-one结构式

2-methyl-4,7-bi...

~71%

7-hydroxy-2-methyl-4-phenylmethoxy-3H-isoindol-1-one结构式

7-hydroxy-2-met...

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4,7-dihydroxy-2-methyl-2,3-dihydro-1-isoindoledione结构式

4,7-dihydroxy-2...

~%

7-hydroxy-2-methyl-4-phenylmethoxy-3H-isoindol-1-one结构式

7-hydroxy-2-met...

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2-methyl-4,7-bis(phenylmethoxy)isoindole-1,3-dione结构式

2-methyl-4,7-bi...

~%

7-hydroxy-2-methyl-4-phenylmethoxy-3H-isoindol-1-one结构式

7-hydroxy-2-met...

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4,7-di(benzyloxy)-3-hydroxy-2-methyl-2,3-dihydro-1-isoindolone结构式

4,7-di(benzylox...

~%

7-hydroxy-2-methyl-4-phenylmethoxy-3H-isoindol-1-one结构式

7-hydroxy-2-met...

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3,6-二羟基邻苯二甲腈结构式

3,6-二羟基邻苯二甲腈

~%

7-hydroxy-2-methyl-4-phenylmethoxy-3H-isoindol-1-one结构式

7-hydroxy-2-met...

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4-benzyloxy-7-methoxy-2-methyl-2,3-dihydro-1-isoindolone结构式

4-benzyloxy-7-m...

~99%

4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

4-hydroxy-7-met...

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4,7-dihydroxy-2-methyl-2,3-dihydro-1-isoindoledione结构式

4,7-dihydroxy-2...

~%

4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

4-hydroxy-7-met...

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7-hydroxy-2-methyl-4-phenylmethoxy-3H-isoindol-1-one结构式

7-hydroxy-2-met...

~%

4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

4-hydroxy-7-met...

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2-methyl-4,7-bis(phenylmethoxy)-3H-isoindol-1-one结构式

2-methyl-4,7-bi...

~%

4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

4-hydroxy-7-met...

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2-methyl-4,7-bis(phenylmethoxy)isoindole-1,3-dione结构式

2-methyl-4,7-bi...

~%

4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

4-hydroxy-7-met...

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4,7-di(benzyloxy)-3-hydroxy-2-methyl-2,3-dihydro-1-isoindolone结构式

4,7-di(benzylox...

~%

4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

4-hydroxy-7-met...

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3,6-二羟基邻苯二甲腈结构式

3,6-二羟基邻苯二甲腈

~%

4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

4-hydroxy-7-met...

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4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

4-hydroxy-7-met...

~52%

5-bromo-4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

5-bromo-4-hydro...

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4,7-dihydroxy-2-methyl-2,3-dihydro-1-isoindoledione结构式

4,7-dihydroxy-2...

~%

5-bromo-4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

5-bromo-4-hydro...

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4-benzyloxy-7-methoxy-2-methyl-2,3-dihydro-1-isoindolone结构式

4-benzyloxy-7-m...

~%

5-bromo-4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

5-bromo-4-hydro...

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7-hydroxy-2-methyl-4-phenylmethoxy-3H-isoindol-1-one结构式

7-hydroxy-2-met...

~%

5-bromo-4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

5-bromo-4-hydro...

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2-methyl-4,7-bis(phenylmethoxy)-3H-isoindol-1-one结构式

2-methyl-4,7-bi...

~%

5-bromo-4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

5-bromo-4-hydro...

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2-methyl-4,7-bis(phenylmethoxy)isoindole-1,3-dione结构式

2-methyl-4,7-bi...

~%

5-bromo-4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

5-bromo-4-hydro...

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4,7-di(benzyloxy)-3-hydroxy-2-methyl-2,3-dihydro-1-isoindolone结构式

4,7-di(benzylox...

~%

5-bromo-4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

5-bromo-4-hydro...

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3,6-二羟基邻苯二甲腈结构式

3,6-二羟基邻苯二甲腈

~%

5-bromo-4-hydroxy-7-methoxy-2-methyl-3H-isoindol-1-one结构式

5-bromo-4-hydro...

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2-bromo-5,8-dimethoxy-1-naphthol结构式

2-bromo-5,8-dim...

碘甲烷结构式

~93%

2-bromo-1,5,8-trimethoxynaphthalene结构式

2-bromo-1,5,8-t...

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未登录结构式

4-溴-2(5h)-呋喃酮结构式

4-溴-2(5h)-呋喃酮

~89%

3-(1,5,8-trimethoxynaphthalen-2-yl)-2H-furan-5-one结构式

3-(1,5,8-trimet...

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2-bromo-1,5,8-trimethoxynaphthalene结构式

2-bromo-1,5,8-t...

~%

3-(1,5,8-trimethoxynaphthalen-2-yl)-2H-furan-5-one结构式

3-(1,5,8-trimet...

查看详情