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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues

…, MR Jacob, Q Zhang, SI Khan, D Ferreira…

文献索引：Babu, K. Suresh; Li, Xing-Cong; Jacob, Melissa R.; Zhang, Qifeng; Khan, Shabana I.; Ferreira, Daneel; Clark, Alice M. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7877 - 7886

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被引用次数: 62

摘要

Coruscanone A, a plant-derived cyclopentenedione derivative, showed potent in vitro antifungal activity against Candida albicans and Cryptococcus neoformans comparable to amphotericin B and fluconazole. A series of analogues have been synthesized by modification of the cyclopentenedione ring, the enolic methoxy functionality, and the side chain styryl moiety of this natural product lead. A structurally close 1, 4-benzoquinone ...

柠康酸酐结构式

(Phenylcarbonylmethylene)triphenylphosphorane结构式

(Phenylcarbonyl...

~56%

3-methyl-5-phenacylidenefuran-2-one结构式

3-methyl-5-phen...

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苯甲酰甲基三苯基溴化膦结构式

苯甲酰甲基三苯基溴化膦

~%

3-methyl-5-phenacylidenefuran-2-one结构式

3-methyl-5-phen...

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2-溴苯乙酮结构式

~%

3-methyl-5-phenacylidenefuran-2-one结构式

3-methyl-5-phen...

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3-methyl-5-phenacylidenefuran-2-one结构式

3-methyl-5-phen...

~50%

2-benzoyl-3-hydroxy-4-methylcyclopenta-2,4-dien-1-one结构式

2-benzoyl-3-hyd...

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苯甲酰甲基三苯基溴化膦结构式

苯甲酰甲基三苯基溴化膦

~%

2-benzoyl-3-hydroxy-4-methylcyclopenta-2,4-dien-1-one结构式

2-benzoyl-3-hyd...

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2-溴苯乙酮结构式

~%

2-benzoyl-3-hydroxy-4-methylcyclopenta-2,4-dien-1-one结构式

2-benzoyl-3-hyd...

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(Phenylcarbonylmethylene)triphenylphosphorane结构式

(Phenylcarbonyl...

~%

2-benzoyl-3-hydroxy-4-methylcyclopenta-2,4-dien-1-one结构式

2-benzoyl-3-hyd...

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2-methoxy-1,4-bis(methoxymethoxy)benzene结构式

2-methoxy-1,4-b...

~90%

1-bromo-4-methoxy-2,5-bis(methoxymethoxy)benzene结构式

1-bromo-4-metho...

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2-甲氧基对苯二酚结构式

2-甲氧基对苯二酚

~%

1-bromo-4-methoxy-2,5-bis(methoxymethoxy)benzene结构式

1-bromo-4-metho...

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1-bromo-4-methoxy-2,5-bis(methoxymethoxy)benzene结构式

1-bromo-4-metho...

碘甲烷结构式

~90%

1-methoxy-2,5-bis(methoxymethoxy)-4-methylbenzene结构式

1-methoxy-2,5-b...

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2-甲氧基对苯二酚结构式

2-甲氧基对苯二酚

~%

1-methoxy-2,5-bis(methoxymethoxy)-4-methylbenzene结构式

1-methoxy-2,5-b...

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2-methoxy-1,4-bis(methoxymethoxy)benzene结构式

2-methoxy-1,4-b...

~%

1-methoxy-2,5-bis(methoxymethoxy)-4-methylbenzene结构式

1-methoxy-2,5-b...

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苄叉丙酮结构式

~%

4-phenyl-1-(triphenyl-λ5-phosphanylidene)but-3-en-2-one结构式

4-phenyl-1-(tri...

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4-chlorobenzalacetone结构式

4-chlorobenzala...

~67%

1-bromo-4-(4-chlorophenyl)but-3-en-2-one结构式

1-bromo-4-(4-ch...

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1-(2-methoxy-3,6-bismethoxymethoxy-5-methylphenyl)-2-phenylethanol结构式

1-(2-methoxy-3,...

~93%

2-methoxy-5-methyl-3-(2-phenylethenyl)benzene-1,4-diol结构式

2-methoxy-5-met...

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1-methoxy-2,5-bis(methoxymethoxy)-4-methylbenzene结构式

1-methoxy-2,5-b...

~%

2-methoxy-5-methyl-3-(2-phenylethenyl)benzene-1,4-diol结构式

2-methoxy-5-met...

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1-bromo-4-methoxy-2,5-bis(methoxymethoxy)benzene结构式

1-bromo-4-metho...

~%

2-methoxy-5-methyl-3-(2-phenylethenyl)benzene-1,4-diol结构式

2-methoxy-5-met...

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2-甲氧基对苯二酚结构式

2-甲氧基对苯二酚

~%

2-methoxy-5-methyl-3-(2-phenylethenyl)benzene-1,4-diol结构式

2-methoxy-5-met...

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2-methoxy-1,4-bis(methoxymethoxy)benzene结构式

2-methoxy-1,4-b...

~%

2-methoxy-5-methyl-3-(2-phenylethenyl)benzene-1,4-diol结构式

2-methoxy-5-met...

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4-(2-呋喃基)-3-丁烯-2-酮结构式

4-(2-呋喃基)-3-丁烯-2-酮

~60%

1-bromo-4-(furan-2-yl)but-3-en-2-one结构式

1-bromo-4-(fura...

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4-(2-噻吩基)-3-丁烯-2-酮结构式

4-(2-噻吩基)-3-丁烯-2-酮

~59%

1-bromo-4-thiophen-2-ylbut-3-en-2-one结构式

1-bromo-4-thiop...

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(E)-1-bromo-4-phenylbut-3-en-2-one结构式

(E)-1-bromo-4-p...

三苯基膦结构式

~86%

(2-oxo-4-phenylbut-3-enyl)-triphenylphosphanium,bromide结构式

(2-oxo-4-phenyl...

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苄叉丙酮结构式

~%

(2-oxo-4-phenylbut-3-enyl)-triphenylphosphanium,bromide结构式

(2-oxo-4-phenyl...

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1-bromo-4-(furan-2-yl)but-3-en-2-one结构式

1-bromo-4-(fura...

~%

4-(furan-2-yl)-1-(triphenyl-λ5-phosphanylidene)but-3-en-2-one结构式

4-(furan-2-yl)-...

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4-(2-呋喃基)-3-丁烯-2-酮结构式

4-(2-呋喃基)-3-丁烯-2-酮

~%

4-(furan-2-yl)-1-(triphenyl-λ5-phosphanylidene)but-3-en-2-one结构式

4-(furan-2-yl)-...

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1-bromo-4-thiophen-2-ylbut-3-en-2-one结构式

1-bromo-4-thiop...

~%

4-thiophen-2-yl-1-(triphenyl-λ5-phosphanylidene)but-3-en-2-one结构式

4-thiophen-2-yl...

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4-(2-噻吩基)-3-丁烯-2-酮结构式

4-(2-噻吩基)-3-丁烯-2-酮

~%

4-thiophen-2-yl-1-(triphenyl-λ5-phosphanylidene)but-3-en-2-one结构式

4-thiophen-2-yl...

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