Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride

H Zhao, RG Luo, D Wei, SV Malhotra

文献索引：Zhao, Hua; Luo, Robert G.; Wei, Dean; Malhotra, Sanjay V. Enantiomer, 2002 , vol. 7, # 1 p. 1 - 3

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被引用次数: 19

摘要

The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step- reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.