Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams

…, R Morigi, M Chiericozzi, A Fraccari, I Galatulas…

文献索引：Andreani, Aldo; Locatelli, Alessandra; Leoni, Alberto; Morigi, Rita; Chiericozzi, Michele; Fraccari, Alessandra; Galatulas, Iraklis; Salvatore, Gaetano European Journal of Medicinal Chemistry, 1998 , vol. 33, # 11 p. 905 - 909

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被引用次数: 15

摘要

The synthesis of pyridylmethylene lactams and indolylmethylene-2-indolinones is reported. These compounds were tested for their cytotoxic and positive inotropic activity. The presence of both the effects (coanthracyclinic activity) was confirmed in some of the indolylmethylene-2-indolinones.