Acyclic analogs of nucleosides: Synthesis and in vitro antiviral activity of benzimidazoles and benzotriazoles

AÉ Yavorskii, LN Reshot'ko, AA Kucheryavenko…

文献索引：Yavorskii, A. E.; Reshot'ko, L. N.; Kucheryavenko, A. A.; Florent'ev, V. L. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 6 p. 481 - 486 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 6 p. 714 - 719

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被引用次数: 1

摘要

One of the most promising approaches to the development of novel antiviral drugs is the synthesis of acyclic analogs of nucieosides. This approachto the synthesis of biologically active compounds was predicted over ten years ago [2], and has been confirmed by the discovery of such highly active antiviral drugs as 9-(4-hydroxy-2-oxa-butyl) guanine (acyclovir), 9-(4-hydroxy-3-hydroxymethyl-2-oxabutyl) guanine (BIOLF-62),(S)-9-(2, 3- ...