Copper??Catalyzed Aerobic Oxidative Annulation and Carbon??Carbon Bond Cleavage of Arylacetamides: Domino Synthesis of Fused Quinazolinones

J Sun, Q Tan, W Yang, B Liu…

文献索引：Sun, Jie; Tan, Qitao; Yang, Wusong; Liu, Bingxin; Xu, Bin Advanced Synthesis and Catalysis, 2014 , vol. 356, # 2-3 p. 388 - 394

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被引用次数: 17

摘要

Abstract: An efficient copper-catalyzed tandem aerobic oxidative annulation and carbon- carbon bond cleavage reaction was developed from easily accessible arylacetamides, which provides a direct approach for the domino synthesis of a vast array of tricyclic or tetracyclic fused quinazolinone alkaloid structures. A plausible reaction mechanism is proposed involving an aerobic benzylic oxidation/cyclization/decarbonylation cascade. ...