Synthesis and anti??Helicobacter pylori activity of 4??(coumarin??3??yl) thiazol??2??ylhydrazone derivatives

…, A Granese, S Carradori, M D'Ascenzio…

文献索引：Chimenti, Franco; Bizzarri, Bruna; Bolasco, Adriana; Secci, Daniela; Chimenti, Paola; Granese, Arianna; Carradori, Simone; D'Ascenzio, Melissa; Scaltrito, M. Maddalena; Sisto, Francesca Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 6 p. 1269 - 1274

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被引用次数: 15

摘要

INTRODUCTION Helicobacter pylori are spiral-shaped Gram-negative bacteria with polar flagella that live near the surface of the human gastric mucosa. They have evolved specific mechanisms to avoid the bactericidal acid environment in the gastric lumen to survive near, to attach to, and to communicate with the human gastric epithelium and host immune system. This interaction sometimes results in severe gastric pathology. In fact, H. pylori ...