Biocatalytic syntheses of chiral non-racemic 2-hydroxyalkanephosphonates

…, J Drabowicz, P Kiełbasiński, M Mikołajczyk

文献索引：Zurawinski, Remigiusz; Nakamura, Kaoru; Drabowicz, Jozef; Kielbasinski, Piotr; Mikolajczyk, Marian Tetrahedron Asymmetry, 2001 , vol. 12, # 22 p. 3139 - 3145

全文：HTML全文

被引用次数: 39

摘要

A series of 2-oxoalkanephosphonates 2 were screened for reduction with Geotrichum candidum. Only diethyl 2-oxopropanephosphonate 2a underwent asymmetric reduction to give (+)-(R)-diethyl 2-hydroxypropanephosphonate 3a with 98% ee In turn, a series of racemic 2-hydroxyalkanephosphonates 3 were acetylated under kinetic resolution conditions in the presence of various lipases to give the corresponding 2- ...