An efficient total synthesis of bastadin 6 (), a cyclic tetramer of brominated tyrosine derivatives from the marine sponge, Ianthella basta, with selective anti-angiogenic activity, was accomplished. We developed a novel Ce (IV)-mediated oxidative coupling reaction of 2, 6-dibromophenols to give the diaryl ether derivatives, the characteristic segment of. Condensation of two segments and subsequent intramolecular macrocyclization gave ...
