Process research and scale-up of a commercialisable route to maraviroc (UK-427,857), a CCR-5 receptor antagonist

…, SJ Haycock-Lewandowski, J Long…

文献索引：Ahman, Jens; Birch, Melissa; Haycock-Lewandowski, Sarah J.; Long, James; Wilder, Alexander Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1104 - 1113

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被引用次数: 23

摘要

A six-step synthetic route to the CCR-5 receptor antagonist, Maraviroc (UK-427,857)(1) has been developed and demonstrated at scale in a pilot plant. The route has supported four Pilot-Plant campaigns and has produced multikilogram quantities of 1. Continued development of the synthetic route has resulted in a robust process with improved throughput compared to that of the original synthesis (Haycock-Lewandowski, SJ; Mawby, ...