Laxatives II. Relationship between structure and potency

MH Hubacher, S Doernberg

文献索引：Hubacher,M.H.; Doernberg,S. Journal of Pharmaceutical Sciences, 1964 , vol. 53, # 9 p. 1067 - 1072

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被引用次数: 20

摘要

By MAX H. HUBACHER and SIDNEY DOERNBERG ... The Relative Laxative Potency of a series of compounds was determined. These were mainly phenols containing certain groupings. We find two phenolic HO- groups, preferably in the configuration (p) HO-C&-&-C&&-OH (p') in the syn- thetic organic laxatives most commonly employed commarcially. T he two exhibiting the highest otency also contained a mtrogen ring. The Macaque monkey (Mucaca mulatta ...