Carbocyclic thromboxane A2

…, RL Magolda, DA Claremon

文献索引：Nicolaou; Magolda; Claremon Journal of the American Chemical Society, 1980 , vol. 102, # 4 p. 1404 - 1409

全文：HTML全文

被引用次数: 79

摘要

Abstract: The total synthesis of carbocyclic thromboxane A2 (CTA2)(5) and its hydroxy epimer (5b) has been achieved both in racemic and optically active forms. Bicyclo [3.1. Ilheptan-2-one (6), synthesized by two alternative routes, was converted to the key intermediate 7, which was efficiently transformed to the carbocyclic thromboxane A2 skeleton by a cuprate 1, 4 addition to introduce the lower side chain followed by ...