N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents

DY Maeda, W Williams, WE Kim, LN Thatcher…

文献索引：Maeda, Dean Y.; Williams, Wanda; Kim, Wes E.; Thatcher, Linn N.; Bowen, Wayne D.; Coop, Andrew Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 3 p. 497 - 500

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被引用次数: 40

摘要

To delineate the differences between the structural requirements necessary for recognition at sigma-1 and sigma-2 receptors, a range of phenethyl-and phenylpropylpiperidines were evaluated in binding assays. Phenethylpiperidines were found to favor sigma-1 receptors, ...