Abstract Five bichalcones (5-1∼ 5-4, 9) were prepared by the reaction of biphenyl-4, 4′- dicarbaldehyde (4) and 4, 4′-dioxybenzaldehyde (8) with the respective acetophenone analogs via Claisen-Schmidt condensation and were then fully identified by 1H-NMR, 13 C- NMR and mass analyses.