Highly Efficient Narasaka–Heck Cyclizations Mediated by P (3, 5??(CF3) 2C6H3) 3: Facile Access to N??Heterobicyclic Scaffolds

A Faulkner, JF Bower

文献索引：Faulkner, Adele; Bower, John F. Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1675 - 1679

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被引用次数: 39

摘要

In recent years, the drive for more potent and selective drugs has seen medicinal chemistry move away from “flat” compounds and become increasingly interested in evaluating chiral “3D” drug candidates.[1] The complexities associated with accessing such molecules require the development of more efficient and versatile entries to chiral scaffolds. In this regard, and given the importance of nitrogen,[2] new methods for the efficient and ...