Brominated 4??(Trifluoromethyl) pyrimidines: A Convenient Access to Versatile Intermediates

L Ondi, O Lefebvre, M Schlosser

文献索引：Ondi, Levente; Lefebvre, Olivier; Schlosser, Manfred European Journal of Organic Chemistry, 2004 , # 17 p. 3714 - 3718

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被引用次数: 16

摘要

Abstract An expedient route to all three monobrominated and all three dibrominated isomers of 4-(trifluoromethyl) pyrimidine, and to several other halogenated pyrimidines, is described. Key steps are the electrophilic introduction of the halogen in the 5-position of 2-or 4- pyrimidinones, the bromodeoxygenation of pyrimidinones or thiopyrimidinones using phosphorus tribromide, and the partial debromination of dibromo-4-(trifluoromethyl) ...