Tetrahedron letters

A two-step biomimetic synthesis of antimalarial robustadials A and B

SB Bharate, IP Singh

文献索引：Bharate, Sandip B.; Singh, Inder Pal Tetrahedron Letters, 2006 , vol. 47, # 39 p. 7021 - 7024

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被引用次数: 21

摘要

The antimalarial robustadials A and B have been synthesized in two steps starting from commercially available phloroglucinol comprising a key biomimetic three-component reaction that involves in situ generation of an o-quinone methide via Knoevenagel condensation and subsequent Diels–Alder cycloaddition with (−)-β-pinene.