3, 4-Disubstituted Δ 3-pyrrolin-2-ones were prepared in high yields via 5-tosyl-Δ 3-pyrrolin-2- ones (4) starting from 2-tosylpyrroles regioselectively. The compounds 4 were found to be useful intermediates for the preparation of a variety of Δ 3-pyrrolin-2-one derivatives. The reactions of 4 with various nucleophiles and active methylene compounds bearing an appropriate leaving group are described.
[Michael, Joseph P.; De Koning, Charles R.; Malefetse, Tshepo J.; Yillah, Ibrahim Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3510 - 3517]
