Scale-up synthesis of the dopamine uptake inhibitor GBR-12909

MD Ironside, PM Sugathapala…

文献索引：Organic Process Research and Development, , vol. 6, # 5 p. 621 - 627

全文：HTML全文

被引用次数: 2

摘要

... As per intermediate 2, it was discovered that crude dihydrochloride salt could be formed more efficiently by treating the organic extracts with 2.2 equiv of concentrated hydrochloric acid at 20 ... This new procedure eliminated 1,4-dioxane from the process and simplified ...