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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. XXII. A Convenient Method for Synthesizing 3, 5, 7-Trihydroxy-6-methoxyflavones.

…, K Shibata, K Yamashita, Y KAWAMURA…

文献索引：Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451

全文：HTML全文

被引用次数: 27

摘要

The demethylation of 3, 4-dioxygenated 6-methoxy-2-isopropoxyacetophenones was studied and it was found that 4-benzyloxy-6-hydroxy-3-methoxy-2-isopropoxyacetophenone was easily obtained from 4-benzyloxy-3, 6-dimethoxy-2-isopropoxyacetophenone by selective demethylation with anhydrous aluminum bromide-sodium iodide in acetonitrile. The acetophenone was converted into 7-benzyloxy-3-hydroxy-6-methoxy-5- ...

7-(benzyloxy)-2-(4-(benzyloxy)-3-methoxyphenyl)-3,5-dihydroxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~74%

Spinacetin结构式

4-benzyloxy-3-methoxybenzoyl chloride结构式

4-benzyloxy-3-m...

~%

Spinacetin结构式

1-(2-hydroxy-3,6-dimethoxy-4-phenylmethoxyphenyl)ethanone结构式

1-(2-hydroxy-3,...

~%

Spinacetin结构式

1-(2,4-dihydroxy-3,6-dimethoxy-phenyl)ethanone结构式

1-(2,4-dihydrox...

~%

Spinacetin结构式

未登录结构式

~%

Spinacetin结构式

1-(4-(benzyloxy)-2-isopropoxy-3,6-dimethoxyphenyl)ethan-1-one结构式

1-(4-(benzyloxy...

~%

Spinacetin结构式

7-(benzyloxy)-2-(4-(benzyloxy)-3-methoxyphenyl)-5-isopropoxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~%

Spinacetin结构式

未登录结构式

~%

Spinacetin结构式

未登录结构式

~%

Spinacetin结构式

未登录结构式

~%

Spinacetin结构式

7-(benzyloxy)-2-(4-(benzyloxy)-3-methoxyphenyl)-5-isopropoxy-6-methoxy-4-oxo-4H-chromen-3-yl 4-methylbenzenesulfonate结构式

7-(benzyloxy)-2...

~%

Spinacetin结构式

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3,5-dihydroxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~85%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

4-苄氧基苯甲酰氯结构式

4-苄氧基苯甲酰氯

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

1-(2-hydroxy-3,6-dimethoxy-4-phenylmethoxyphenyl)ethanone结构式

1-(2-hydroxy-3,...

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

1-(2,4-dihydroxy-3,6-dimethoxy-phenyl)ethanone结构式

1-(2,4-dihydrox...

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

未登录结构式

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

1-(4-(benzyloxy)-2-isopropoxy-3,6-dimethoxyphenyl)ethan-1-one结构式

1-(4-(benzyloxy...

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-isopropoxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-hydroxy-5-isopropoxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

未登录结构式

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

未登录结构式

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-hydroxy-6-methoxy-4-oxo-4H-chromen-3-yl 4-methylbenzenesulfonate结构式

7-(benzyloxy)-2...

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-isopropoxy-6-methoxy-4-oxo-4H-chromen-3-yl 4-methylbenzenesulfonate结构式

7-(benzyloxy)-2...

~%

6-甲氧基山奈酚结构式

6-甲氧基山奈酚

1-(2,4-dihydroxy-3,6-dimethoxy-phenyl)ethanone结构式

1-(2,4-dihydrox...

~%

1-(2-hydroxy-3,6-dimethoxy-4-phenylmethoxyphenyl)ethanone结构式

1-(2-hydroxy-3,...

氯化苄结构式

~%

1-(2-hydroxy-3,6-dimethoxy-4-phenylmethoxyphenyl)ethanone结构式

1-(2-hydroxy-3,...

未登录结构式

~88%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

1-(2-hydroxy-3,6-dimethoxy-4-phenylmethoxyphenyl)ethanone结构式

1-(2-hydroxy-3,...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

1-(2,4-dihydroxy-3,6-dimethoxy-phenyl)ethanone结构式

1-(2,4-dihydrox...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

未登录结构式

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

1-(4-(benzyloxy)-2-isopropoxy-3,6-dimethoxyphenyl)ethan-1-one结构式

1-(4-(benzyloxy...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-5-isopropoxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one结构式

7-(benzyloxy)-5...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

1-(4-(benzyloxy)-6-hydroxy-2-isopropoxy-3-methoxyphenyl)-3-(4-methoxyphenyl)propane-1,3-dione结构式

1-(4-(benzyloxy...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-3-hydroxy-5-isopropoxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one结构式

7-(benzyloxy)-3...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

2-acetyl-5-(benzyloxy)-3-isopropoxy-4-methoxyphenyl 4-methoxybenzoate结构式

2-acetyl-5-(ben...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-3-yl 4-methylbenzenesulfonate结构式

7-(benzyloxy)-5...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-5-isopropoxy-6-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-3-yl 4-methylbenzenesulfonate结构式

7-(benzyloxy)-5...

~%

3,5,7-trihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-2-(3-(benzyloxy)-4-methoxyphenyl)-3,5-dihydroxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~89%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

1-(2-hydroxy-3,6-dimethoxy-4-phenylmethoxyphenyl)ethanone结构式

1-(2-hydroxy-3,...

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

1-(2,4-dihydroxy-3,6-dimethoxy-phenyl)ethanone结构式

1-(2,4-dihydrox...

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

未登录结构式

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

1-(4-(benzyloxy)-2-isopropoxy-3,6-dimethoxyphenyl)ethan-1-one结构式

1-(4-(benzyloxy...

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-2-(3-(benzyloxy)-4-methoxyphenyl)-5-isopropoxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

1-(3-(benzyloxy)-4-methoxyphenyl)-3-(4-(benzyloxy)-6-hydroxy-2-isopropoxy-3-methoxyphenyl)propane-1,3-dione结构式

1-(3-(benzyloxy...

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-2-(3-(benzyloxy)-4-methoxyphenyl)-3-hydroxy-5-isopropoxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

未登录结构式

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-2-(3-(benzyloxy)-4-methoxyphenyl)-5-isopropoxy-6-methoxy-4-oxo-4H-chromen-3-yl 4-methylbenzenesulfonate结构式

7-(benzyloxy)-2...

~%

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxychromen-4-one结构式

3,5,7-trihydrox...

7-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-3,5-dihydroxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~71%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

1-(2,4-bis(benzyloxy)-3,6-dimethoxyphenyl)ethanone结构式

1-(2,4-bis(benz...

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

1-(2-hydroxy-3,6-dimethoxy-4-phenylmethoxyphenyl)ethanone结构式

1-(2-hydroxy-3,...

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

1-(2,4-dihydroxy-3,6-dimethoxy-phenyl)ethanone结构式

1-(2,4-dihydrox...

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

未登录结构式

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

1-(4-(benzyloxy)-2-isopropoxy-3,6-dimethoxyphenyl)ethan-1-one结构式

1-(4-(benzyloxy...

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

未登录结构式

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

7-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-3-hydroxy-5-isopropoxy-6-methoxy-4H-chromen-4-one结构式

7-(benzyloxy)-2...

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

未登录结构式

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

2-acetyl-5-(benzyloxy)-3-isopropoxy-4-methoxyphenyl 3,4-bis(benzyloxy)benzoate结构式

2-acetyl-5-(ben...

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

未登录结构式

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

7-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-5-isopropoxy-6-methoxy-4-oxo-4H-chromen-3-yl 4-methylbenzenesulfonate结构式

7-(benzyloxy)-2...

~%

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone结构式

2-(3,4-dihydrox...

1-(2-hydroxy-3,4,6-trimethoxy-phenyl)ethanone结构式

1-(2-hydroxy-3,...

2-溴丙烷结构式

~%

1-(3,4,6-trimethoxy-2-propan-2-yloxyphenyl)ethanone结构式

1-(3,4,6-trimet...