Phenyl sulfur mustard derivatives of distamycin A

…, M Caldarelli, L Capolongo, C Geroni, S Mazzini…

文献索引：Cozzi, Paolo; Beria, Italo; Caldarelli, Marina; Capolongo, Laura; Geroni, Cristina; Mazzini, Stefania; Ragg, Enzio Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1653 - 1656

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被引用次数: 16

摘要

The design, synthesis, and cytotoxic activity of novel benzoyl and cinnamoyl sulfur mustard derivatives of distamycin A are described and structure–activity relationships are discussed. These sulfur mustards are more potent cytotoxics than corresponding nitrogen mustards in spite of the lower alkylating power, while their sulfoxide analogues are substantially inactive. Cinnamoyl sulfur mustard derivative (7) proved to be one of the most active distamycin- ...