Design and synthesis of a series of 6-substituted-2-pyridinylmethylamine derivatives as novel, high-affinity, selective agonists at 5-HT1A receptors

B Vacher, B Bonnaud, P Funes, N Jubault…

文献索引：Journal of Medicinal Chemistry, , vol. 41, # 25 p. 5070 - 5083

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被引用次数: 28

摘要

... Journal of Medicinal Chemistry. ... Oxidation of 7i,j 19,20 and cleavage of the acetal group produced the aldehydes 8k,l. Addition of CH 3 MgBr on the nitrile 7f gave the methyl ketone 7g which was converted to the pyrazole 7h using known chemistry. ...