Chemistry and biology of diazonamide A: First total synthesis and confirmation of the true structure

KC Nicolaou, DYK Chen, X Huang, T Ling…

文献索引：Nicolaou; Chen, David Y.-K.; Huang, Xianhai; Ling, Taotao; Bella, Marco; Snyder, Scott A. Journal of the American Chemical Society, 2004 , vol. 126, # 40 p. 12888 - 12896

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被引用次数: 142

摘要

With the addition of a tenth ring, the exchange of an oxygen atom for a nitrogen in the heart of the molecule, and a different terminal residue, the revised architecture for diazonamide A (1) provided an even more challenging molecular puzzle for chemical synthesis than its predecessor. In this article, we detail the first successful total synthesis of diazonamide A, an endeavor which not only verified its proper connectivities and established the ...