Synthesis and pharmacological evaluations of novel 2H-benzo [b][1, 4] oxazin-3 (4H)-one derivatives as a new class of anti-cancer agents

…, V Sunku, FJ Piedrafita, VR Veeramaneni, M Pal

文献索引：Rajitha, Chittipaka; Dubey; Sunku, Venkataiah; Javier Piedrafita; Veeramaneni, Venugopal Rao; Pal, Manojit European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 4887 - 4896

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被引用次数: 16

摘要

The synthesis of novel 2H-benzo [b][1, 4] oxazin-3 (4H)-one derivatives has been carried out using trifluoroacetic anhydride/phosphoric acid mediated C–C bond forming reaction as a key step. This method does not require the use of environmentally harmful AlCl3 or moisture sensitive acid chloride. A number of compounds containing the benzooxazinone moiety attached to a five-membered central heterocyclic ring was synthesized and tested for their ...