Tetrahedron

Carbohydrate chiral-pool approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates

B Doboszewski, P Herdewijn

文献索引：Doboszewski, Bogdan; Herdewijn, Piet Tetrahedron, 2008 , vol. 64, # 23 p. 5551 - 5562

全文：HTML全文

被引用次数: 13

摘要

Batumin 1, 2E,10Z,12E-20-(3-aminocarboxy)-2-methyl-1-oxobutylamino-7-methylene-17-oxo -19-oxy-3,5,15-trimethyleicosa-2,10,12-trienoic acid, is an antibiotic produced by the strains of Pseudomonas batumici ( Fig. 1). 1 It shows very good activity particularly against Gram-negative bacteria, eg, Staphylococcus aureus, 2 and 3 which pose a serious health problem due to their resistance against antibiotics in current use. Batumin's basic structural elucidation was ...