Tetrahedron letters

A rapid and convenient synthesis of novel 1-imino-2, 3-dihydro-1H-pyrazino [2, 1,-b] quinazolin-5-ones

M de Fatima Pereira, FR Alexandre, V Thiéry…

文献索引：Pereira, Maria De Fatima; Alexandre, Francois Rene; Thiery, Valerie; Besson, Thierry Tetrahedron Letters, 2004 , vol. 45, # 15 p. 3097 - 3099

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被引用次数: 15

摘要

Exploring original approaches for the synthesis of therapeutic agents having a quinazoline part, we discovered that novel 3, 4-dihydro-2H-pyrazino [2, 1,-b] quinazolines) may be rapidly and easily obtained via the chemistry of 4, 5-dichloro-1, 2, 3-dithiazolium chloride). Our synthetic approach of this reaction is described with the aim of obtaining a well- controlled access to this very rarely described pyrazino [2, 1,-b] quinazoline skeleton.