Tetrahedron letters

Biomimetic total synthesis of colneleic acid and its function as a lipoxygenase inhibitor

EJ Corey, R Nagata, SW Wright

文献索引：Corey, E. J.; Nagata, Ryu; Wright, Stephen W. Tetrahedron Letters, 1987 , vol. 28, # 42 p. 4917 - 4920

被引用次数: 27

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A biomimetic synthesis of colneleic acid (2) from 9(S)-hydroperoxy-10(E),12(Z)-octadecadienoic acid (1) is reported. The lipoxygenase of potato which converts linoleic acid to 1 was found to be strongly inhibited by acid 2 (K i = 8μM). ... Obtained by aerobic incubation of linoleic ...