New amino derivatives of 1, 2, 3-triazolo [4, 5-d] pyrimidines and their affinity towards A 1 and A 2A adenosine receptors

…, G Giannaccini, I Giorgi, O Livi, A Lucacchini…

文献索引：Betti, Laura; Biagi, Giuliana; Giannaccini, Gino; Giorgi, Irene; Livi, Oreste; Lucacchini, Antonio; Manera, Clementina; Scartoni, Valerio European Journal of Medicinal Chemistry, 1999 , vol. 34, # 10 p. 867 - 875

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被引用次数: 12

摘要

Starting from the appropriate azides (4-chlorobenzyl-, 2-thiophenemethyl-, 2-fluorobenzyl-, and 4-fluorobenzylazides) in which the variation of the substituent is at the basis of the four series of derivatives (a–d), the 7-aminosubstituted 1, 2, 3-triazolo [4, 5-d] pyrimidines 4 were prepared by a well known synthetic route. The biological activity of compounds 4 was expected on the basis of the presence of particular substituents on N (7), and these ...